Stimulustriggered fate conversion of somatic cells into pluripotency in chronic wounds in human beings. Pdf here we report a unique cellular reprogramming phenomenon, called stimulustriggered acquisition of pluripotency stap, which requires neither. Obokata h1, wakayama t2, sasai y3, kojima k4, vacanti mp5. Stimulus triggered fate conversion of somatic cells into pluripotency. Here we report a unique cellular reprogramming phenomenon, called stimulus triggered acquisition of pluripotency stap, which requires. Direct reprogramming of somatic cells into induced neurons. In stap, strong external stimuli such as a transient lowph stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Stimulustriggered fate conversion of somatic cells into pluripotency in chronic.
From chemically to physically induced pluripotency in stem cell. Here we report a unique cellular reprogramming phenomenon, called stimulustriggered acquisition of pluripotency stap, which requires neither nuclear transfer nor the introduction of transcription factors. Pdf stimulustriggered fate conversion of somatic cells. Stimulustriggered acquisition of pluripotency wikipedia.
Hereafter, we refer to the fate conversion from somatic cells into pluripotent cells by strong external stimuli such as low ph as stimulustriggered acquisition of pluripotency stap andtheresultantcellsasstapcells. Reprogramming in response to environmental stress has been observed in plants but not so far in mammalian cells. Stimulustriggered fate conversion of somatic cells into pluripotency overview of attention for article published in nature, january 2014 altmetric badge. Stimulustriggered fate conversion of somatic cells into. Through realtime imaging of stap cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to stap cells by reprogramming rather than selection. Stimulustriggered fate conversion of somatic cells. The fates of the somatic cells that form the bulk of the mammalian body are thought to be largely determined by the time the cellular differentiation processes of development have been completed. Here we report a unique cellular reprogramming phenomenon, called stimulustriggered acquisition of pluripotency stap, which requires. It was not clear why ordinary cells do not convert into stem cells when subjected to similar stimuli. Pdf stimulus triggered fate conversion of somatic cells. Thus, our findings indicate that epigenetic fate determination of. Stimulustriggered fate conversion of somatic cells into pluripotency.
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